Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521572 | 0.83 | RAF1 (0.35) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL4272236 | 0.81 | RAB9A (0.44) | RAF1BRAF | |
| SCHEMBL4271546 | 0.81 | BRAF (0.32) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL4281251 | 0.80 | BRAF (0.33) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL4562970 | 0.77 | BRAF (0.42) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL1521776 | 0.77 | BRAF (0.36) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL1522007 | 0.76 | BRAF (0.36) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL4271182 | 0.73 | BRAF (0.43) | KRASRAF1BRAFKDRMAP2K2 | |
| SCHEMBL4273911 | 0.73 | RAB9A (0.43) | RAF1BRAF | |
| SCHEMBL4276058 | 0.72 | BRAF (0.45) | KRASRAF1BRAFKDRMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | claimed |