Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118976 | 0.77 | KMT2A (0.45) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4273148 | 0.75 | KMT2A (0.49) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4128711 | 0.71 | ALDH1A1 (0.46) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4119304 | 0.70 | KMT2A (0.46) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL1851522 | 0.70 | MAPT (0.57) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4115321 | 0.69 | ALDH1A1 (0.46) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4272956 | 0.69 | KMT2A (0.48) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4105160 | 0.69 | KMT2A (0.44) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4273196 | 0.69 | KMT2A (0.44) | KMT2AMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4283164 | 0.68 | PIM1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |