Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720122 | 0.88 | ALDH1A1 (0.39) | ALDH1A1HTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL16719505 | 0.79 | BIRC5 (0.39) | ALDH1A1HTTLMNABIRC5MAPT | |
| SCHEMBL16720656 | 0.79 | KCNH2 (0.45) | ALDH1A1HTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL145426 | 0.78 | BIRC5 (0.44) | HTTSMN1; SMN2BIRC5PRKACA | |
| SCHEMBL1078090 | 0.77 | BIRC5 (0.61) | ALDH1A1HTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL29896757 | 0.77 | BIRC5 (0.61) | ALDH1A1HTTSMN1; SMN2HPGDLMNA | |
| SCHEMBL16719873 | 0.76 | PARP1 (0.43) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL16720593 | 0.76 | CYP19A1 (0.45) | BIRC5MAPT | |
| SCHEMBL16720871 | 0.74 | POLB (0.39) | ALDH1A1HTTHPGDKDM4EBIRC5 | |
| SCHEMBL10193341 | 0.73 | ROCK1 (0.55) | ALDH1A1SMN1; SMN2HPGDKDM4EROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |