Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148060 | 0.86 | KCNH2 (0.49) | KCNH2BIRC5CYP19A1ALDH1A1KDM4E | |
| SCHEMBL16719505 | 0.83 | BIRC5 (0.39) | BIRC5CYP19A1ALDH1A1MAPTLMNA | |
| SCHEMBL145426 | 0.82 | BIRC5 (0.44) | BIRC5CYP19A1SMN1; SMN2HTT | |
| SCHEMBL16719992 | 0.81 | HPGDS (0.36) | KCNH2BIRC5MAPTCDC7CDK2 | |
| SCHEMBL16720593 | 0.79 | CYP19A1 (0.45) | BIRC5CYP19A1MAPTCDC7CDK2 | |
| SCHEMBL4273291 | 0.79 | ALDH1A1 (0.39) | BIRC5ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL16719663 | 0.78 | MAPT (0.34) | KCNH2MAPTCDC7CDK2ROCK1 | |
| SCHEMBL16720871 | 0.78 | POLB (0.39) | BIRC5ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL16720518 | 0.76 | ROCK2 (0.43) | BIRC5CYP19A1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL16720528 | 0.76 | MAPT (0.42) | BIRC5ALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |