Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13572502 | 0.86 | LMNA (0.38) | LMNAALDH1A1RAB9ASIGMAR1MAPT | |
| SCHEMBL4273350 | 0.84 | KDM1A (0.35) | KDM1AAGTR2SMN1; SMN2 | |
| SCHEMBL4270118 | 0.82 | RAB9A (0.38) | LMNAALDH1A1RAB9AKDM1ASIGMAR1 | |
| SCHEMBL13573332 | 0.78 | CNR1 (0.36) | LMNAALDH1A1RAB9ANPC1L1POLB | |
| SCHEMBL4197420 | 0.74 | SMN1; SMN2 (0.46) | LMNAALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL12266075 | 0.73 | LMNA (0.46) | LMNAALDH1A1RAB9AMAPTL3MBTL1 | |
| SCHEMBL4206478 | 0.72 | POLB (0.39) | LMNAALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL4049868 | 0.68 | SMN1; SMN2 (0.41) | LMNAALDH1A1L3MBTL1POLBGRM5 | |
| SCHEMBL4048593 | 0.68 | SMN1; SMN2 (0.41) | LMNAALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL823358 | 0.67 | POLB (0.44) | LMNAALDH1A1RAB9APOLBPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312335-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-12-17 | — | — | US | disclosed |
| EP-1942736-A2 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007050510-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312335-A1 | Hiv Integrase Inhibitors | RECQL, TYMP, POLR2H | LMNA 3382/4885ALDH1A1 2058/4885RAB9A 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.