Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234137 | 0.87 | TLR7 (0.44) | EGFRSRCTLR7TLR9TLR8 | |
| SCHEMBL4264419 | 0.83 | TLR7 (0.41) | EGFRSRCTLR7TLR9TLR8 | |
| SCHEMBL4230072 | 0.78 | CYP1A2 (0.41) | KDM4ETLR7TLR9TLR8 | |
| SCHEMBL4232788 | 0.78 | SUV39H2 (0.43) | EGFRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL4225661 | 0.77 | RECQL (0.44) | KDM4ETLR7TLR9TLR8ADORA2A | |
| SCHEMBL4274358 | 0.77 | HSP90AA1 (0.46) | EGFRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL4050303 | 0.77 | TLR7 (0.43) | EGFRSRCTLR7TLR9TLR8 | |
| SCHEMBL4215652 | 0.76 | MTOR (0.39) | EGFRSRCKDM4ENPC1RAB9A | |
| SCHEMBL4227399 | 0.75 | TLR7 (0.41) | EGFRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL4228176 | 0.75 | TLR7 (0.44) | FGFR1FGFR2FGFR4FGFR3TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | EGFR 1469/4885FGFR1 233/4885SRC 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.