Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225661 | 0.91 | RECQL (0.44) | TLR7TLR9TLR8MEN1KMT2A | |
| SCHEMBL4218258 | 0.87 | MAPT (0.46) | HSP90AB1TLR7TLR9TLR8MEN1 | |
| SCHEMBL4224648 | 0.86 | TLR7 (0.48) | TLR7TLR9TLR8FGFR1FGFR2 | |
| SCHEMBL4232788 | 0.84 | SUV39H2 (0.43) | HSP90AA1HSP90AB1TLR7TLR9TLR8 | |
| SCHEMBL4264419 | 0.82 | TLR7 (0.41) | HSP90AA1HSP90AB1TLR7TLR9TLR8 | |
| SCHEMBL4232920 | 0.81 | CRHR1 (0.42) | TLR7TLR9TLR8CRHR1ADORA2A | |
| SCHEMBL4231672 | 0.81 | IDO1 (0.42) | HSP90AA1TLR7TLR9TLR8MEN1 | |
| SCHEMBL4219502 | 0.80 | TLR7 (0.45) | HSP90AB1TLR7TLR9TLR8KMT2A | |
| SCHEMBL4046724 | 0.79 | TLR7 (0.48) | TLR7TLR9TLR8ADORA1EGFR | |
| SCHEMBL4049411 | 0.79 | ADORA1 (0.55) | TLR7TLR9TLR8KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | HSP90AA1 3482/4885HSP90AB1 3256/4885TLR7 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.