Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.59 |
| ▸ | CASR | P41180 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283355 | 0.91 | PTGDR2 (0.61) | PTGDR2CASRALDH1A1GAAHSD17B10 | |
| SCHEMBL4272589 | 0.90 | PTGDR2 (0.71) | PTGDR2CASRALDH1A1GAALPAR1 | |
| SCHEMBL3159495 | 0.87 | PTGDR2 (0.79) | PTGDR2CASRLPAR1 | |
| SCHEMBL4281837 | 0.84 | PTGDR2 (0.59) | PTGDR2CASRKMT2A | |
| SCHEMBL4266987 | 0.84 | PTGDR2 (0.63) | PTGDR2CASRALDH1A1LPAR1MAPT | |
| SCHEMBL4275484 | 0.84 | PTGDR2 (0.63) | PTGDR2CASRALDH1A1LPAR1KMT2A | |
| SCHEMBL4275413 | 0.83 | PTGDR2 (0.60) | PTGDR2CASRGAALPAR1 | |
| SCHEMBL4271817 | 0.83 | PTGDR2 (0.59) | PTGDR2CASRALDH1A1LPAR1KMT2A | |
| SCHEMBL4272587 | 0.80 | PTGDR2 (0.74) | PTGDR2CASRALDH1A1GAALPAR1 | |
| SCHEMBL4275915 | 0.79 | PTGDR2 (0.58) | PTGDR2CASRALDH1A1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |