Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.53 |
| ▸ | PTGIR | P43119 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275416 | 0.84 | PTGDR2 (0.60) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL4274289 | 0.80 | PTGDR2 (0.53) | PTGDR2PTGIRPPARAPPARG | |
| SCHEMBL4274216 | 0.79 | PTGDR2 (0.52) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL3174468 | 0.77 | PTGDR2 (0.64) | PTGDR2PTGIRPPARAPPARG | |
| SCHEMBL3174387 | 0.76 | PTGDR2 (0.72) | PTGDR2PTGIRPPARAPPARGFKBP1A | |
| SCHEMBL4273827 | 0.76 | PTGDR2 (0.51) | PTGDR2PTGIRPPARAPPARG | |
| SCHEMBL8803298 | 0.72 | PTGDR2 (0.60) | PTGDR2PTGIRPPARAPPARG | |
| SCHEMBL2769715 | 0.71 | PPARA (0.74) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL3169110 | 0.70 | PPARA (0.72) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL8804548 | 0.70 | PTGDR2 (0.57) | PTGDR2PTGIRPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |