Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.60 |
| ▸ | PTGIR | P43119 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274289 | 0.93 | PTGDR2 (0.53) | PTGDR2PTGIRPPARAPPARGMAPK1 | |
| SCHEMBL4274216 | 0.93 | PTGDR2 (0.52) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL4273827 | 0.89 | PTGDR2 (0.51) | PTGDR2PTGIRPPARAPPARGMAPK1 | |
| SCHEMBL4272582 | 0.84 | PTGDR2 (0.42) | PTGDR2 | |
| SCHEMBL4276584 | 0.84 | PTGDR2 (0.53) | PTGDR2PTGIRPPARAPPARGFFAR1 | |
| SCHEMBL4271051 | 0.80 | L3MBTL1 (0.41) | PTGDR2PTGIR | |
| SCHEMBL3174468 | 0.78 | PTGDR2 (0.64) | PTGDR2PTGIRPPARAPPARGABCB1 | |
| SCHEMBL4281834 | 0.76 | RAB9A (0.42) | PTGDR2 | |
| SCHEMBL3165320 | 0.75 | PTGDR2 (1.00) | PTGDR2PTGIRPPARAPPARG | |
| SCHEMBL4274205 | 0.75 | PTGDR2 (0.56) | PTGDR2PTGIRPPARAPPARGMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |