Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275416 | 0.89 | PTGDR2 (0.60) | PTGDR2MAPK1PPARAPPARGPTGIR | |
| SCHEMBL4281834 | 0.88 | RAB9A (0.42) | PTGDR2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4274289 | 0.83 | PTGDR2 (0.53) | PTGDR2MAPK1PPARAPPARGPTGIR | |
| SCHEMBL4274216 | 0.82 | PTGDR2 (0.52) | PTGDR2KMT2APPARAPPARGSMN1; SMN2 | |
| SCHEMBL3165103 | 0.80 | PTGDR2 (0.78) | PTGDR2MAPK1MEN1KMT2ARAB9A | |
| SCHEMBL4272582 | 0.78 | PTGDR2 (0.42) | PTGDR2MEN1KMT2A | |
| SCHEMBL4276584 | 0.76 | PTGDR2 (0.53) | PTGDR2PPARAPPARGPTGIR | |
| SCHEMBL3174468 | 0.71 | PTGDR2 (0.64) | PTGDR2PPARAPPARGPTGIR | |
| SCHEMBL3951459 | 0.71 | NPC1 (0.76) | MAPK1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4271051 | 0.71 | L3MBTL1 (0.41) | PTGDR2SMN1; SMN2PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |