Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851200 | 0.91 | KMT2A (0.43) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4280778 | 0.80 | KMT2A (0.45) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4277770 | 0.80 | KMT2A (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1849605 | 0.77 | ALDH1A1 (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4282044 | 0.77 | NPC1 (0.48) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4552596 | 0.76 | TSHR (0.46) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1850058 | 0.76 | ALDH1A1 (0.48) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1854752 | 0.74 | USP30 (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1851649 | 0.74 | USP30 (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1850429 | 0.74 | KMT2A (0.42) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |