Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4277770 | 0.92 | KMT2A (0.47) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4282044 | 0.90 | NPC1 (0.48) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL1851938 | 0.86 | TSHR (0.51) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4280778 | 0.83 | KMT2A (0.45) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4277803 | 0.80 | TSHR (0.50) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL1850058 | 0.77 | ALDH1A1 (0.48) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL1851581 | 0.76 | NPC1 (0.51) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4277173 | 0.76 | KMT2A (0.41) | TSHRALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4282729 | 0.76 | KMT2A (0.41) | TSHRALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL4277433 | 0.75 | KMT2A (0.39) | TSHRALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |