Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27573441 | 0.84 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1RXRA | |
| SCHEMBL695016 | 0.80 | MAPT (0.40) | MAPTL3MBTL1SLC6A4APP | |
| SCHEMBL3211927 | 0.78 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL7774298 | 0.78 | ALDH1A1 (0.44) | MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL28396455 | 0.76 | TSHR (0.47) | MAPTMAPK1TDP1L3MBTL1NPC1 | |
| SCHEMBL1190605 | 0.76 | MAPT (0.52) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL16950963 | 0.75 | CYP1A2 (0.39) | MAPTTDP1L3MBTL1HTR2CHTR2B | |
| SCHEMBL510440 | 0.75 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1RXRA | |
| SCHEMBL7293597 | 0.75 | MAPT (0.59) | MAPTMAPK1TDP1L3MBTL1RXRA | |
| SCHEMBL8115540 | 0.75 | SLC6A2 (0.39) | MAPTMAPK1L3MBTL1HTR1ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TIE1, KDR, FLT1 | MAPT 3596/4885MAPK1 856/4885TDP1 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.