Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Probutate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 2/20 | 0.82 |
| ▸ | PGR | P06401 | 4/20 | 0.82 |
| ▸ | AR | P10275 | 3/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.82 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Probutate SCHEMBL30507561 | 1.00 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL4778 | 1.00 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL4290122 | 1.00 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL14339602 | 1.00 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL122187 | 0.97 | PGR (0.85) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL4290159 | 0.97 | PGR (0.85) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL605474 | 0.97 | NR3C2 (0.85) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL4278627 | 0.95 | PGR (0.91) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL10858602 | 0.94 | PGR (0.81) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL10535271 | 0.94 | NR3C2 (0.80) | PGRARCHRM1NR3C2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4290962-A | HYDROCORTISONE 17-BUTYRATE-21-PROPIONATE, USEFUL AS AN ANTIINFLAMMATORY AGENT | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1981-09-22 | — | — | US | claimed |
| JP-59139315-A | — | — | None | — | — | JP | disclosed |
| US-20090233892-A1 | Topical Compositions Comprising Hydrocortisone Butyrate | GLENMARK GENERICS LTD (IN) | 2009-09-17 | — | — | US | disclosed |
| US-4794107-A | HYDROCORTISONE BUTYRATE PROPIONATE, PROPYLENE GLYCOL, SURFACTANTS, PARAFIN HYDROCARBONS; ANTIINFLAMMATORY AGENTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1988-12-27 | — | — | US | disclosed |
| US-4794106-A | HYDROCORTISONE BUTYRATE PROPIONATE, HIGHER PARAFFINIC HYDROCARBON, SURFACTANT | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1988-12-27 | — | — | US | disclosed |
| JP-S59139315-A | CREAM AGENT | TAISHO PHARMACEUT CO LTD | 1984-08-10 | — | — | JP | disclosed |
| US-4290962-A | HYDROCORTISONE 17-BUTYRATE-21-PROPIONATE, USEFUL AS AN ANTIINFLAMMATORY AGENT | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1981-09-22 | — | — | US | disclosed |
| US-4290962-A | HYDROCORTISONE 17-BUTYRATE-21-PROPIONATE, USEFUL AS AN ANTIINFLAMMATORY AGENT | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1981-09-22 | — | — | US | disclosed |