Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.36 |
| ▸ | USP19 | O94966 | 3/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281482 | 0.94 | HCRTR1 (0.39) | KDM4EALDH1A1HCRTR1HCRTR2USP19 | |
| SCHEMBL4290851 | 0.94 | USP19 (0.37) | ALDH1A1HCRTR1HCRTR2USP19HRH3 | |
| SCHEMBL4287621 | 0.93 | HCRTR1 (0.41) | HCRTR1HCRTR2USP19 | |
| SCHEMBL4288893 | 0.93 | USP19 (0.36) | ALDH1A1HCRTR1HCRTR2USP19HRH3 | |
| SCHEMBL4281907 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2USP19 | |
| Hydrochloric Acid SCHEMBL4282670 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2USP19 | |
| SCHEMBL4295402 | 0.92 | HCRTR1 (0.40) | HCRTR1HCRTR2USP19 | |
| SCHEMBL13705381 | 0.92 | HCRTR1 (0.38) | ALDH1A1HCRTR1HCRTR2USP19 | |
| SCHEMBL4284595 | 0.92 | NPC1 (0.41) | KDM4EALDH1A1HCRTR1HCRTR2USP19 | |
| SCHEMBL4283819 | 0.91 | HCRTR1 (0.37) | ALDH1A1HCRTR1HCRTR2USP19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | KDM4E 760/4885ALDH1A1 388/4885HCRTR1 3147/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | KDM4E 760/4885ALDH1A1 388/4885HCRTR1 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.