Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12838201 | 0.98 | RAD52 (0.60) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL3446318 | 0.93 | RAD52 (0.72) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL24333102 | 0.86 | RAD52 (0.59) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL3605906 | 0.85 | RAD52 (0.53) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| Hydrochloric Acid SCHEMBL3598388 | 0.84 | RAD52 (0.51) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL3585953 | 0.84 | RAD52 (0.51) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL4649100 | 0.84 | RAD52 (0.51) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| Hydrochloric Acid SCHEMBL4884203 | 0.82 | RAD52 (0.50) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL20402780 | 0.82 | RAD52 (0.50) | RAD52SIGMAR1CARM1PRMT6PRMT8 | |
| SCHEMBL20614282 | 0.81 | RAD52 (0.58) | RAD52SIGMAR1HRH3CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928457-A1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A | Istituto Europeo di Oncologia S.r.l. (IT) | 2015-10-14 | — | — | EP | claimed |
| WO-2014086790-A1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2014-06-12 | — | — | WO | claimed |
| EP-2928457-A1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A | Istituto Europeo di Oncologia S.r.l. (IT) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014086790-A1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2014-06-12 | — | — | WO | disclosed |
| WO-2009131246-A1 | SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009131246-A1 | SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | WO | disclosed |