Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 8/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282318 | 0.77 | CYP2A13 (0.42) | CYP2A13CYP2C9ALOX15HSD17B10HIF1A | |
| SCHEMBL27812255 | 0.76 | SMN1; SMN2 (0.49) | ALOX15CXCR4KDM4ELMNAHTT | |
| SCHEMBL15859936 | 0.75 | KDM4E (0.67) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL27812185 | 0.75 | CXCR4 (0.53) | CYP2A13CYP2C9ALOX15HSD17B10HIF1A | |
| SCHEMBL27832316 | 0.74 | SMN1; SMN2 (0.41) | HIF1AEPAS1ALDH1A1KMT2ACXCR4 | |
| SCHEMBL4287156 | 0.74 | ALDH1A1 (0.44) | ALOX15HSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL11193326 | 0.73 | CYP2A13 (0.75) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL5695515 | 0.71 | CYP2A13 (0.50) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2649768 | 0.71 | CYP2A13 (0.57) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL16463965 | 0.71 | CYP2A13 (0.45) | CYP2A13CYP2C9ALOX15HSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TIE1, KDR, FLT1 | CYP2A13 1775/4885CYP2C9 853/4885ALOX15 1583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.