Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 7/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278526 | 0.83 | ACHE (0.41) | ALDH1A1PLK1KDM4ETSHRHSD17B10 | |
| SCHEMBL13440252 | 0.81 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB | |
| SCHEMBL3256406 | 0.81 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB | |
| SCHEMBL4280900 | 0.77 | AMY1A (0.42) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL4279896 | 0.75 | PLK1 (0.43) | PLK1KDM4ETSHRCYP3A4CYP2C9 | |
| SCHEMBL4282487 | 0.75 | PDE10A (0.38) | ALDH1A1PLK1KDM4ELMNAMAPT | |
| SCHEMBL13440255 | 0.75 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB | |
| SCHEMBL3255648 | 0.75 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB | |
| SCHEMBL3255723 | 0.74 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB | |
| SCHEMBL13440261 | 0.74 | PLK1 (0.49) | PLK1PLK3PIK3CDNUAK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124615-A9 | Benzimidazole Thiophene Compounds | KUNTZ KEVIN | 2009-05-14 | — | — | US | disclosed |
| US-20080300247-A1 | Benzimidazole Thiophene Compounds | KUNTZ KEVIN | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124615-A9 | Benzimidazole Thiophene Compounds | ABCB1, CYP3A5, ABCG2 | PARP1 2463/4885PARP2 2208/4885ALDH1A1 1060/4885 |
| US-20080300247-A1 | Benzimidazole Thiophene Compounds | ABCB1, CYP3A5, ABCG2 | PARP1 2463/4885PARP2 2208/4885ALDH1A1 1060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.