Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.77 |
| ▸ | PRKCG | P05129 | 4/20 | 0.77 |
| ▸ | PRKACA | P17612 | 4/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.77 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.77 |
| ▸ | NEK4 | P51957 | 4/20 | 0.77 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.77 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.77 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.77 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.77 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.77 |
| ▸ | AKT1 | P31749 | 3/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.77 |
| ▸ | CDK2 | P24941 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | AKT2 | P31751 | 3/20 | 0.77 |
| ▸ | GSK3A | P49840 | 3/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283652 | 0.92 | ROCK1 (0.64) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4291559 | 0.87 | ROCK1 (1.00) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4280764 | 0.85 | ROCK1 (0.54) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4292230 | 0.79 | ROCK1 (0.84) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4282293 | 0.79 | ROCK1 (0.84) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4286997 | 0.79 | ROCK1 (0.84) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4284244 | 0.77 | ROCK1 (0.54) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4280545 | 0.77 | ROCK1 (0.77) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL4286792 | 0.76 | ROCK1 (0.56) | ROCK1PRKCGPRKACARPS6KB1IRAK1 | |
| SCHEMBL13457014 | 0.75 | SCD (0.77) | WNT3ACYP3A4ABL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | claimed |
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | disclosed |
| WO-2009126635-A1 | 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ROCK1, ROCK2, RHOA | ROCK1 1/4885PRKCG 199/4885PRKACA 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.