Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.54 |
| ▸ | PRKACA | P17612 | 3/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.54 |
| ▸ | PRKX | P51817 | 3/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | PRKCG | P05129 | 2/20 | 0.54 |
| ▸ | AKT1 | P31749 | 2/20 | 0.54 |
| ▸ | CLK2 | P49760 | 2/20 | 0.54 |
| ▸ | NEK4 | P51957 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.54 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286792 | 0.92 | ROCK1 (0.56) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4280764 | 0.89 | ROCK1 (0.54) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4286942 | 0.83 | MAP4K4 (0.67) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4284779 | 0.83 | MAP4K4 (0.67) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4287157 | 0.83 | ROCK1 (0.56) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4282384 | 0.83 | ROCK1 (0.56) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4279054 | 0.81 | MAP4K4 (0.57) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4282684 | 0.77 | ROCK1 (0.77) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4287920 | 0.76 | MAP4K4 (0.53) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 | |
| SCHEMBL4281966 | 0.76 | MAP4K4 (0.53) | ROCK1CSNK1DPRKACARPS6KB1IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | claimed |
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ROCK1, ROCK2, RHOA | ROCK1 1/4885CSNK1D 289/4885PRKACA 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.