SCHEMBL4282701

SCHEMBL4282701

Cc1nc(NC(=O)c2ccc3c(c2)CCNC3)sc1Cc1ccccc1OCC(C)C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 5/20 0.53
RAB9A P51151 2/20 0.49
TDP1 Q9NUW8 1/20 0.49
SMN1; SMN2 Q16637 6/20 0.41
HPGD P15428 5/20 0.41
KMT2A Q03164 4/20 0.41
LMNA P02545 3/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 3/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MAP3K5 Q99683 1/20 0.39
MAPT P10636 3/20 0.39
HTT P42858 1/20 0.39
WNT1 P04628 2/20 0.38
GSK3B P49841 2/20 0.38
DYRK1A Q13627 2/20 0.38
ROCK2 O75116 1/20 0.38
F2 P00734 1/20 0.37
PLG P00747 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4283252 0.99 PTGER1 (0.54) PTGER1RAB9ATDP1SMN1; SMN2HPGD
SCHEMBL4275871 0.90 HPGD (0.46) PTGER1RAB9ATDP1SMN1; SMN2HPGD
Hydrochloric Acid SCHEMBL4278219 0.89 HPGD (0.46) PTGER1RAB9ATDP1SMN1; SMN2HPGD
SCHEMBL4285373 0.84 SMN1; SMN2 (0.45) PTGER1RAB9ATDP1SMN1; SMN2HPGD
Hydrochloric Acid SCHEMBL4279458 0.83 SMN1; SMN2 (0.44) PTGER1RAB9ATDP1SMN1; SMN2HPGD
SCHEMBL4282184 0.82 HPGD (0.52) RAB9ATDP1SMN1; SMN2HPGDKMT2A
Hydrochloric Acid SCHEMBL4287316 0.82 HPGD (0.52) RAB9ATDP1SMN1; SMN2HPGDKMT2A
SCHEMBL13573324 0.82 HPGD (0.45) RAB9ATDP1SMN1; SMN2HPGDKMT2A
SCHEMBL4274873 0.78 SMN1; SMN2 (0.48) RAB9ATDP1SMN1; SMN2HPGDKMT2A
SCHEMBL4276192 0.78 HPGD (0.58) PTGER1RAB9ATDP1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009150196-A1 N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE SMITHKLINE BEECHAM CORPORATION (US) 2009-12-17 WO claimed
WO-2009150196-A1 N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE SMITHKLINE BEECHAM CORPORATION (US) 2009-12-17 WO disclosed