Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287197 | 0.82 | AGXT (0.37) | AGXTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5141171 | 0.73 | AGXT (0.40) | AGXTMEN1KMT2ALMNASLC16A3 | |
| SCHEMBL8189516 | 0.70 | AGXT (0.61) | AGXTALDH1A1SMN1; SMN2SIGMAR1MAPT | |
| SCHEMBL5141914 | 0.70 | AGXT (0.39) | AGXTMEN1KMT2ASLC16A3SLC16A1 | |
| SCHEMBL4507051 | 0.65 | AGXT (0.65) | AGXTALDH1A1SMN1; SMN2SIGMAR1MAPT | |
| SCHEMBL5134153 | 0.64 | GAA (0.41) | ALDH1A1SMN1; SMN2POLBMAPTKDM4E | |
| SCHEMBL17276273 | 0.63 | AGXT (0.49) | AGXTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28276177 | 0.63 | LMNA (0.55) | AGXTALDH1A1SMN1; SMN2SIGMAR1MAPT | |
| SCHEMBL26616472 | 0.63 | POLB (0.50) | ALDH1A1SMN1; SMN2SIGMAR1POLBMAPT | |
| SCHEMBL18295011 | 0.63 | AGXT (0.65) | AGXTALDH1A1SIGMAR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |