SCHEMBL4287197

SCHEMBL4287197

CCCc1cc(N(Cc2cccc(N3CCOCC3)c2)CC2CCCCC2)n(C)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGXT P21549 1/20 0.37
HCRTR1 O43613 1/20 0.36
HCRTR2 O43614 1/20 0.36
HTR1A P08908 1/20 0.35
HTR1D P28221 1/20 0.35
HTR1B P28222 1/20 0.35
HTR2C P28335 1/20 0.35
PRKDC P78527 4/20 0.34
ATM Q13315 4/20 0.33
PIK3C3 Q8NEB9 2/20 0.33
AOC3 Q16853 1/20 0.33
L3MBTL3 Q96JM7 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CTSL P07711 1/20 0.32
TTK P33981 1/20 0.32
PRMT6 Q96LA8 1/20 0.32
MEN1 O00255 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 1/20 0.31
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4285889 0.85 AGXT (0.38) AGXTHCRTR1HCRTR2HTR1AHTR1D
SCHEMBL4282837 0.82 HTR7 (0.40) AGXTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4282621 0.78 AGXT (0.36) AGXTHCRTR1HCRTR2HTR1AHTR1D
SCHEMBL4128912 0.76 PDE5A (0.41) MEN1KMT2AALDH1A1
SCHEMBL4142910 0.73 HSP90AA1 (0.37) AGXTHTR1AHTR1DHTR1BPRKDC
SCHEMBL4123059 0.73 PDE5A (0.34) HCRTR1HCRTR2HTR2CPRKDCATM
SCHEMBL8032543 0.72 HSP90AA1 (0.35) AGXTHCRTR1HCRTR2HTR2CPRKDC
SCHEMBL4128842 0.71 KDM4E (0.35) AGXTHCRTR1HCRTR2HTR1AHTR1D
SCHEMBL8189516 0.69 AGXT (0.61) AGXTHCRTR1HCRTR2ATMAOC3
SCHEMBL5141914 0.69 AGXT (0.39) AGXTHCRTR1HCRTR2HTR1AHTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009071706-A1 PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES GALAPAGOS NV (BE) 2009-06-11 WO disclosed