SCHEMBL4283635

SCHEMBL4283635

COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FNTA P49354 16/20 1.00
PGGT1B P53609 11/20 1.00
TDP1 Q9NUW8 3/20 1.00
FNTB P49356 14/20 0.84
TAS1R3 Q7RTX0 4/20 0.45
TAS1R1 Q7RTX1 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29392871 1.00 FNTA (1.00) FNTAPGGT1BTDP1FNTBTAS1R3
SCHEMBL16136630 1.00 FNTA (1.00) FNTAPGGT1BTDP1FNTBTAS1R3
Trifluoroacetic Acid SCHEMBL16499777 0.94 FNTA (0.89) FNTAPGGT1BTDP1FNTBTAS1R3
Trifluoroacetic Acid SCHEMBL16499780 0.94 FNTA (0.89) FNTAPGGT1BTDP1FNTBTAS1R3
Trifluoroacetic Acid SCHEMBL30104219 0.94 FNTA (0.89) FNTAPGGT1BTDP1FNTBTAS1R3
SCHEMBL16136644 0.91 FNTA (1.00) FNTAPGGT1BTDP1FNTB
SCHEMBL1804295 0.91 FNTA (1.00) FNTAPGGT1BTDP1FNTB
SCHEMBL14169141 0.91 FNTA (0.87) FNTAPGGT1BTDP1FNTB
SCHEMBL16499927 0.91 FNTA (1.00) FNTAPGGT1BTDP1FNTB
SCHEMBL25211622 0.90 FNTA (0.81) FNTAPGGT1BTDP1FNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11382971-B2 Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant TSINGHUA UNIVERSITY (CN) 2022-07-12 US disclosed
US-20210008084-A1 MEVALONATE PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF TSINGHUA UNIVERSITY (CN) 2021-01-14 US disclosed
US-20190321465-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT TSINGHUA UNIVERSITY (CN) 2019-10-24 US disclosed
US-20120108632-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA ALCON RESEARCH, LTD. (US) 2012-05-03 US disclosed
WO-2011088126-A2 TREATMENT OF VIRAL INFECTION WITH PRENYLTRANSFERASE INHIBITORS EIGER BIOPHARMACEUTICALS, INC. (US) 2011-07-21 WO disclosed
US-20110112053-A1 PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2011-05-12 US disclosed
US-20100120851-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA ALCON RESEARCH, LTD. (US) 2010-05-13 US disclosed
US-20100120851-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA ALCON RESEARCH, LTD. (US) 2010-05-13 US disclosed
WO-2008080110-A1 METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR ALCON, INC. (CH) 2008-07-03 WO disclosed
US-20080153819-A1 METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR NOVARTIS AG (CH) 2008-06-26 US disclosed
US-20070232675-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA ALCON MANUFACTURING, LTD. (US) 2007-10-04 US disclosed
US-20070232675-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA ALCON MANUFACTURING, LTD. (US) 2007-10-04 US disclosed
US-20070219208-A1 Methods for Treating Cancer NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110112053-A1 PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS RHOA, LIPG, KDR FNTA 161/4885PGGT1B 735/4885TDP1 2726/4885
US-20070232675-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA FNTA, PTAR1, RHOA FNTA 1/4885PGGT1B 8/4885TDP1 1351/4885
US-20190321465-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT GGPS1, HMGCR, COASY FNTA 5/4885PGGT1B 251/4885TDP1 3476/4885
US-20100120851-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA FNTA, PTAR1, RHOA FNTA 1/4885PGGT1B 8/4885TDP1 1351/4885
US-11382971-B2 Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant GGPS1, HMGCR, COASY FNTA 5/4885PGGT1B 247/4885TDP1 3503/4885
US-20210008084-A1 MEVALONATE PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF PDCD1, CD274, PDCD5 FNTA 42/4885PGGT1B 154/4885TDP1 3364/4885
US-20120108632-A1 PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA FNTA, PTAR1, RHOA FNTA 1/4885PGGT1B 8/4885TDP1 1351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.