Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4279963 | 0.99 | MAPT (0.60) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL4285057 | 0.90 | MAPT (0.60) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4279689 | 0.89 | MAPT (0.59) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL4284053 | 0.88 | GAA (0.57) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4276562 | 0.87 | GAA (0.56) | MAPTSMN1; SMN2CYP1A2LMNASCD | |
| SCHEMBL4281323 | 0.86 | SCD (0.56) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4289761 | 0.86 | SCD (0.56) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL4288598 | 0.86 | KMT2A (0.61) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4279918 | 0.85 | KMT2A (0.60) | MAPTSMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL4283271 | 0.82 | POLB (0.56) | MAPTSMN1; SMN2CYP1A2LMNASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | claimed |