Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY4R | P50391 | 6/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.37 |
| ▸ | NPY1R | P25929 | 5/20 | 0.37 |
| ▸ | NPY2R | P49146 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521788 | 0.87 | SIRT6 (0.48) | SIRT6SIRT1SIRT5MEN1ALDH1A1 | |
| SCHEMBL1521539 | 0.86 | NPY4R (0.46) | SIRT6SIRT1NPY4RNPY5RNPY1R | |
| SCHEMBL1006420 | 0.84 | SIRT6 (0.47) | SIRT6SIRT1SIRT5MEN1ALDH1A1 | |
| SCHEMBL13950767 | 0.82 | SIRT6 (0.51) | SIRT6SIRT1SIRT5GRIA1MEN1 | |
| SCHEMBL1521358 | 0.81 | SIRT6 (0.43) | SIRT6SIRT1SIRT5NPY4RNPY5R | |
| SCHEMBL1521162 | 0.81 | NPY4R (0.47) | SIRT6SIRT1NPY4RNPY5RNPY1R | |
| SCHEMBL1521603 | 0.81 | SIRT6 (0.43) | SIRT6SIRT1SIRT5NPY4RNPY5R | |
| SCHEMBL1521786 | 0.80 | DPP7 (0.49) | MEN1ALDH1A1KMT2ANPY4RNPY5R | |
| SCHEMBL1521224 | 0.80 | DPP7 (0.49) | MEN1ALDH1A1KMT2ANPY4RNPY5R | |
| SCHEMBL1521341 | 0.80 | NPY4R (0.48) | SIRT6SIRT1NPY4RNPY5RNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404643-B2 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-03-26 | — | — | US | disclosed |
| US-20090105152-A1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090099334-A1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099334-A1 | METASTIN DERIVATIVES AND USE THEREOF | SHBG, GNRHR, INHA | SIRT6 1480/4885SIRT1 890/4885SIRT5 1288/4885 |
| US-20090105152-A1 | METASTIN DERIVATIVES AND USE THEREOF | SHBG, GNRHR, INHA | SIRT6 1480/4885SIRT1 890/4885SIRT5 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.