Pefurazoate

Pefurazoate

SCHEMBL4284449

C=CCCCOC(=O)C(CC)N(Cc1ccco1)C(=O)n1ccnc1.C=CCOC(Cn1ccnc1)c1ccc(Cl)cc1Cl

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 9/20 0.51
LMNA P02545 7/20 0.51
CYP2C9 P11712 7/20 0.51
CYP3A4 P08684 7/20 0.51
CYP1A2 P05177 5/20 0.51
CYP2D6 P10635 5/20 0.51
CYP2C19 P33261 5/20 0.51
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
TSHR P16473 4/20 0.51
ALOX15 P16050 3/20 0.51
TDP1 Q9NUW8 4/20 0.40
NR1I2 O75469 3/20 0.40
NR3C1 P04150 3/20 0.40
CYP17A1 P05093 3/20 0.40
PGR P06401 3/20 0.40
ADRB1 P08588 3/20 0.40
ADORA3 P0DMS8 3/20 0.40
DRD2 P14416 3/20 0.40
SLC6A2 P23975 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pefurazoate SCHEMBL20067 0.84 MAPT (0.35) LMNACYP2C9CYP3A4CYP1A2CYP2C19
(R)-(+)-Pefurazoate SCHEMBL8163178 0.84 MAPT (0.35) LMNACYP2C9CYP3A4CYP1A2CYP2C19
Pefurazoate SCHEMBL27797684 0.83 MAPT (0.35) LMNACYP2C9CYP3A4CYP1A2CYP2C19
Pefurazoate SCHEMBL16194522 0.83 LMNA (0.31) IDO1LMNACYP2C9CYP3A4CYP1A2
Pefurazoate SCHEMBL4059805 0.81 AHR (0.57) ADRB1ADRB3TP53MAPT
Pefurazoate SCHEMBL28180407 0.78 MAPT (0.32) LMNACYP2C9CYP3A4CYP1A2CYP2C19
Pefurazoate SCHEMBL28269053 0.78 POLB (0.33) LMNACYP2C9CYP3A4CYP1A2CYP2C19
Pefurazoate SCHEMBL28785223 0.75 MEN1 (0.45) MEN1KMT2ATDP1TP53MAPT
SCHEMBL19186469 0.73 MAPT (0.34) LMNACYP2C9CYP3A4CYP1A2CYP2C19
Enilconazole SCHEMBL28210284 0.72 IDO1 (0.93) IDO1LMNACYP2C9CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109169678-A Bactericide and composition thereof 侨昌现代农业有限公司 2019-01-11 CN disclosed
US-8227573-B2 Utility of phylloplanins as antibiotics, selective fungicides and for enhancing microbial resistance in plants UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2012-07-24 US disclosed
US-20090281038-A1 Phylloplanins Inhibition of Microbial Growth on Organic Materials UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2009-11-12 US disclosed
US-20090215667-A1 Utility of phylloplanins as antibiotics, selective fungicides and for enhancing microbial resistance in plants UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2009-08-27 US disclosed