Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.66 |
| ▸ | CDK1 | P06493 | 6/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 3/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.52 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094919 | 0.83 | CDK1 (0.60) | CDK2CDK1CDK5TDP1KDM4E | |
| SCHEMBL3082573 | 0.79 | CDK1 (1.00) | CDK2CDK1CDK9CDK5TDP1 | |
| SCHEMBL6016549 | 0.76 | CDK2 (0.74) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL1354893 | 0.76 | CDK2 (0.76) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL15117810 | 0.76 | CDK2 (0.75) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL786759 | 0.75 | CDK2 (0.74) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL3300752 | 0.75 | CDK2 (1.00) | CDK2CDK1CDK9CDK5TDP1 | |
| SCHEMBL22355616 | 0.75 | CDK2 (0.78) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL786829 | 0.75 | CDK2 (0.68) | CDK2CDK1FLT3CDK9CDK5 | |
| SCHEMBL786760 | 0.75 | CDK2 (0.74) | CDK2CDK1FLT3CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030019-A1 | PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTI-PROLIFERATIVE PROPERTIES, AND THEIR BIOLOGICAL USES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2009-01-29 | — | — | US | claimed |
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2003-10-02 | — | — | US | claimed |
| EP-1308447-A1 | Purine derivatives having antiproliferative properties and biological uses thereof | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2003-05-07 | — | — | EP | claimed |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2002-04-25 | — | — | US | claimed |
| EP-0874847-A1 | NOVEL PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTIPROLIFERATIVE PROPERTIES, AND BIOLOGICAL USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1998-11-04 | — | — | EP | claimed |
| WO-1997020842-A1 | NOVEL PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTIPROLIFERATIVE PROPERTIES, AND BIOLOGICAL USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 1997-06-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK2 359/4885CDK1 501/4885FLT3 655/4885 |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK2 359/4885CDK1 501/4885FLT3 655/4885 |
| US-20090030019-A1 | PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTI-PROLIFERATIVE PROPERTIES, AND THEIR BIOLOGICAL USES | PNP, TYMP, NUDT1 | CDK2 344/4885CDK1 516/4885FLT3 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.