Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 13/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.53 |
| ▸ | CDK2 | P24941 | 10/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285480 | 0.83 | CDK2 (0.66) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL6817833 | 0.81 | CDK1 (0.63) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL24966176 | 0.81 | CDK1 (0.69) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL2318905 | 0.78 | CDK1 (0.62) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL17628610 | 0.78 | CDK1 (0.79) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL22131204 | 0.76 | CDK5 (0.65) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL6821041 | 0.76 | CDK1 (0.62) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL5196519 | 0.75 | CDK1 (0.55) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL6152647 | 0.75 | CDK1 (0.82) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL1400442 | 0.75 | CDK1 (1.00) | CDK1CDK5CDK2DYRK1ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2003-10-02 | — | — | US | claimed |
| EP-1308447-A1 | Purine derivatives having antiproliferative properties and biological uses thereof | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2003-05-07 | — | — | EP | claimed |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2002-04-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK1 501/4885CDK5 517/4885CDK5R1 881/4885 |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK1 501/4885CDK5 517/4885CDK5R1 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.