SCHEMBL4285489

SCHEMBL4285489

O=C(Cl)c1ccc(OC2CC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.58
EPHX2 P34913 8/20 0.49
MAP4K4 O95819 1/20 0.49
SENP8 Q96LD8 2/20 0.49
SENP6 Q9GZR1 2/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
CASP3 P42574 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
FURIN P09958 1/20 0.46
FAAH O00519 2/20 0.46
SRD5A2 P31213 1/20 0.44
OPRK1 P41145 1/20 0.43
KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1027693 0.92 PARP10 (0.64) PARP10EPHX2MAP4K4SENP8SENP6
SCHEMBL11758749 0.91 PARP10 (0.62) PARP10EPHX2SENP8SENP6ALDH1A1
SCHEMBL3671492 0.90 DGAT1 (0.49) PARP10EPHX2MAP4K4SENP8SENP6
SCHEMBL10188577 0.88 PARP10 (0.47) PARP10EPHX2MAP4K4SENP8SENP6
SCHEMBL197827 0.88 PARP10 (0.50) PARP10EPHX2SENP8SENP6ALDH1A1
SCHEMBL601886 0.86 PARP10 (0.45) PARP10EPHX2ALDH1A1FAAH
SCHEMBL601885 0.86 PARP10 (0.45) PARP10EPHX2ALDH1A1FAAH
SCHEMBL9805576 0.83 ALDH1A1 (0.47) PARP10EPHX2ALDH1A1LMNA
SCHEMBL1977190 0.82 ALDH1A1 (0.70) PARP10EPHX2MAP4K4SENP8SENP6
SCHEMBL28687531 0.81 PDE4D (0.44) PARP10SENP8SENP6ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 PARP10 2557/4885EPHX2 4388/4885MAP4K4 1470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.