Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.55 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.55 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.50 |
| ▸ | SCD | O00767 | 5/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283175 | 0.86 | NAMPT (0.69) | NAMPTSMN1; SMN2TAS2R8ALDH1A1SCD5 | |
| SCHEMBL4283149 | 0.85 | NAMPT (0.66) | NAMPTSMN1; SMN2HCRTR1HCRTR2TAS2R8 | |
| SCHEMBL22557129 | 0.81 | ATR (0.57) | NAMPTHCRTR1HCRTR2RPS6KA2SCD5 | |
| SCHEMBL4508322 | 0.81 | SMN1; SMN2 (0.57) | NAMPTSMN1; SMN2HCRTR1HCRTR2RPS6KA2 | |
| SCHEMBL10195016 | 0.80 | TAS2R8 (0.53) | NAMPTSMN1; SMN2HCRTR1HCRTR2TAS2R8 | |
| SCHEMBL30963203 | 0.79 | HCRTR2 (0.56) | NAMPTSMN1; SMN2HCRTR1HCRTR2TAS2R8 | |
| SCHEMBL3712991 | 0.79 | NAMPT (1.00) | NAMPT | |
| SCHEMBL31224791 | 0.77 | RPS6KA2 (0.49) | NAMPTSMN1; SMN2HCRTR1HCRTR2RPS6KA2 | |
| SCHEMBL6966254 | 0.77 | EGFR (0.70) | NAMPTSMN1; SMN2TAS2R8ALDH1A1MAPT | |
| SCHEMBL838950 | 0.77 | L3MBTL1 (0.61) | NAMPTADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | NAMPT 954/4885SMN1; SMN2 4064/4885HCRTR1 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.