Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432542 | 0.83 | KDR (0.49) | KDRAURKBEGFRALDH1A1USP2 | |
| SCHEMBL4430780 | 0.78 | MAPT (0.55) | KDRAURKBALDH1A1MAPK1MAPT | |
| SCHEMBL30358959 | 0.74 | MAPT (0.61) | ALDH1A1TP53MAPTKMT2AMEN1 | |
| SCHEMBL7369051 | 0.73 | KMT2A (0.54) | EGFRALDH1A1CYP1A2CYP2C19MAPT | |
| SCHEMBL13725360 | 0.72 | AURKA (0.52) | KDREGFRMAPTCHEK1PIM1 | |
| SCHEMBL3269159 | 0.72 | ABCG2 (0.67) | EGFRCYP1A2CYP2C19MAPTPIM1 | |
| SCHEMBL1491116 | 0.72 | HAO1 (0.46) | KDRAURKBCYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL21345464 | 0.70 | ALOX5 (0.58) | KDREGFRALDH1A1TP53MAPT | |
| SCHEMBL14906047 | 0.69 | GRM4 (0.72) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2583806 | 0.69 | MAPT (0.50) | ALDH1A1TP53CYP1A2CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081933-A1 | PYRAZOLOPYRIMIDINES AS P13K LIPID KINASE INHIBITORS | Novartis Ag (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008037477-A1 | PYRAZOLOPYRIMIDINES AS P13K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |