Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SCN4A | P35499 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372198 | 0.81 | ADRA2A (0.46) | MAPTRAB9ANPC1MAPK1L3MBTL1 | |
| SCHEMBL1491116 | 0.79 | HAO1 (0.46) | MAPTRAB9ANPC1SMN1; SMN2PTGIR | |
| SCHEMBL27863099 | 0.79 | CYP1A2 (0.51) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL4286115 | 0.78 | KDR (0.54) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL27700384 | 0.76 | GSK3A (0.43) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL21725013 | 0.75 | POLB (0.52) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL39057 | 0.73 | MAPT (1.00) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL1459772 | 0.73 | MAPT (1.00) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL7330497 | 0.71 | RAB9A (0.74) | MAPTRAB9AGAANPC1MAPK1 | |
| SCHEMBL28142607 | 0.69 | RAB9A (0.64) | MAPTRAB9AGAANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Siena Biotech S.p.A. (IT) | 2009-11-18 | — | — | EP | disclosed |
| US-20080300263-A1 | Pyrazolo [1,5-a] pyrimidine compounds and pharmaceutical compositions containing them | EIRX THERAPEUTICS PLC (IE) | 2008-12-04 | — | — | US | disclosed |
| WO-2008087529-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH S.P.A. (IT) | 2008-07-24 | — | — | WO | disclosed |
| EP-1922321-A1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Eirx Therapeutics Ltd (IE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007017678-A1 | PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EIRX THERAPEUTICS LIMITED (IE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300263-A1 | Pyrazolo [1,5-a] pyrimidine compounds and pharmaceutical compositions containing them | DPYD, TYMS, TYMP | MAPT 3329/4885RAB9A 1434/4885GAA 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.