Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.54 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138948 | 0.84 | KDM4E (0.54) | HRH3MBTD1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL4125514 | 0.84 | HRH3 (0.51) | HRH3MBTD1L3MBTL3L3MBTL1KMT2A | |
| SCHEMBL4131556 | 0.81 | HRH3 (0.60) | HRH3MBTD1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL4143448 | 0.80 | ALDH1A1 (0.59) | HRH3MEN1KMT2AALDH1A1CHRM2 | |
| SCHEMBL4208363 | 0.78 | KDM1A (0.51) | HRH3MBTD1L3MBTL3L3MBTL1MEN1 | |
| SCHEMBL2907506 | 0.76 | HDAC1 (0.65) | HRH3GAAMEN1KMT2AKDM4E | |
| SCHEMBL4259782 | 0.76 | GAA (0.53) | HRH3GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL4135765 | 0.75 | L3MBTL3 (0.70) | HRH3MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL2912150 | 0.75 | HRH3 (0.64) | HRH3GAAMEN1KMT2AKDM4E | |
| SCHEMBL2696081 | 0.75 | CXCR4 (0.67) | HRH3MBTD1L3MBTL3L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |