Tiazofurin

Tiazofurin

SCHEMBL4287

NC(=O)c1csc([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PYGL P06737 2/20 0.53
UMPS P11172 1/20 0.47
IMPDH2 P12268 14/20 0.45
IMPDH1 P20839 10/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiazofurin SCHEMBL1651851 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL7169632 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL4453888 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL23848843 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL2883659 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL23264566 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL13109276 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
Tiazofurin SCHEMBL2883657 1.00 PYGL (0.53) PYGLUMPSIMPDH2IMPDH1
SCHEMBL7832887 0.89 PYGL (0.53) PYGLUMPS
SCHEMBL23375983 0.88 PYGL (0.43) PYGLIMPDH2IMPDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17571 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026103922-A1 CHIMERIC SHUTTLING RECEPTOR 深圳市湾岛细胞科技有限公司 2026-05-21 WO claimed
CN-122060073-A Chimeric shuttle receptors 深圳市湾岛细胞科技有限公司 2026-05-19 CN claimed
WO-2026086785-A1 EUKARYOTIC CELLS EXPRESSING EXOGENOUS INOSINE MONOPHOSPHATE DEHYDROGENASE COMPRISING CHIMERIC ANTIGEN RECEPTOR BINDING TO GUCY2C SHENZHEN WONDERCEL BIOTECHNOLOGY LIMITED (CN) 2026-04-30 WO claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-3515892-B1 COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC (US) 2026-04-15 EP claimed
US-20260085061-A1 PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS SITRYX THERAPEUTICS LIMITED (GB) 2026-03-26 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-4696718-A2 TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY Novartis AG (CH) 2026-02-18 EP claimed
US-20260028400-A1 ANTI-ROR1 ANTIBODY AND USE THEREOF AIMED BIO INC (KR) 2026-01-29 US claimed
EP-0224283-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-06-03 EP claimed
EP-0222425-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-05-20 EP claimed
EP-0221588-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-05-13 EP claimed
EP-0218300-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-04-15 EP claimed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 EP claimed
US-4451648-A VIRICIDE BY MULTI-STEP PROCESS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-05-29 US claimed
US-4446315-A ANTITUMOR AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-05-01 US claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed
EP-0072977-A1 Process for the production of 2-beta-D-ribofuranosylthiazole-4-carboxamide Starks Associates, Incorporated (US) 1983-03-02 EP claimed
EP-0054432-A1 Use of 2-Beta-D-ribofuranosylthiazole-4-carboxamides for the manufacture of medicaments inhibiting malignant tumors VIRATEK, INC. (US) 1982-06-23 EP claimed