SCHEMBL7832887

SCHEMBL7832887

O=C(O)c1csc([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PYGL P06737 5/20 0.53
CASP8 Q14790 1/20 0.43
SLC5A2 P31639 7/20 0.42
GALR3 O60755 1/20 0.41
NR2F2 P24468 1/20 0.41
UMPS P11172 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiazofurin SCHEMBL4453888 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL13109276 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL2883657 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL23264566 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL2883659 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL23848843 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL7169632 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL4287 0.89 PYGL (0.53) PYGLUMPS
Tiazofurin SCHEMBL1651851 0.89 PYGL (0.53) PYGLUMPS
SCHEMBL12901995 0.87 PYGL (0.52) PYGLSLC5A2GALR3NR2F2UMPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4451648-A VIRICIDE BY MULTI-STEP PROCESS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-05-29 US claimed
EP-0072977-A1 Process for the production of 2-beta-D-ribofuranosylthiazole-4-carboxamide Starks Associates, Incorporated (US) 1983-03-02 EP claimed
EP-1000075-A4 METHOD OF PRODUCING TIAZOFURIN AND OTHER C-NUCLEOSIDES ICN PHARMACEUTICALS (US) 2001-09-05 EP disclosed
EP-1000075-A1 METHOD OF PRODUCING TIAZOFURIN AND OTHER C-NUCLEOSIDES ICN Pharmaceuticals, Inc. (US) 2000-05-17 EP disclosed
US-5907036-A Procedures for obtaining ribo-C-nucleosides ICN PHARMACEUTICALS, INC. (US) 1999-05-25 US disclosed
WO-1999000399-A1 METHOD OF PRODUCING TIAZOFURIN AND OTHER C-NUCLEOSIDES ICN PHARMACEUTICALS, INC. (US) 1999-01-07 WO disclosed
EP-0804447-A1 PROCEDURES FOR OBTAINING RIBO-C-NUCLEOSIDES ICN Pharmaceuticals, Inc. (US) 1997-11-05 EP disclosed
WO-1996026212-A1 PROCEDURES FOR OBTAINING RIBO-C-NUCLEOSIDES ICN PHARMACEUTICALS, INC. (US) 1996-08-29 WO disclosed
US-4451648-A VIRICIDE BY MULTI-STEP PROCESS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-05-29 US disclosed
EP-0072977-A1 Process for the production of 2-beta-D-ribofuranosylthiazole-4-carboxamide Starks Associates, Incorporated (US) 1983-03-02 EP disclosed
EP-0072977-A1 Process for the production of 2-beta-D-ribofuranosylthiazole-4-carboxamide Starks Associates, Incorporated (US) 1983-03-02 EP disclosed