⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9675484 | 0.97 | — | — | |
| SCHEMBL2397517 | 0.71 | — | — | |
| SCHEMBL2502618 | 0.69 | — | — | |
| SCHEMBL4859045 | 0.69 | — | — | |
| SCHEMBL6354069 | 0.67 | TDP1 (0.30) | — | |
| Methimazole SCHEMBL41647 | 0.67 | — | — | |
| SCHEMBL1942801 | 0.67 | — | — | |
| SCHEMBL18927708 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL9662049 | 0.65 | — | — | |
| Methimazole SCHEMBL11566410 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280868-B1 | IMIDAZO- AND TRIAZOLOTHIADIAZINES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE AS WELL AS SOME OF THE INTERMEDIATES OBTAINED DURING THE PREPARATION OF SAID COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-06-17 | — | — | EP | claimed |
| EP-0280868-A2 | Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | EP | claimed |
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER IP GMBH (DE) | 2013-11-14 | — | — | US | disclosed |
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER IP GMBH (DE) | 2013-11-14 | — | — | US | disclosed |
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | US | disclosed |
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-1971596-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |
| EP-0280868-B1 | IMIDAZO- AND TRIAZOLOTHIADIAZINES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE AS WELL AS SOME OF THE INTERMEDIATES OBTAINED DURING THE PREPARATION OF SAID COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-06-17 | — | — | EP | disclosed |
| US-4891374-A | INFLAMMATORY RHEUMATIC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-02 | — | — | US | disclosed |
| US-4891374-A | INFLAMMATORY RHEUMATIC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-02 | — | — | US | disclosed |
| EP-0280868-A2 | Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | EP | disclosed |
| EP-0280868-A2 | Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | EP | disclosed |
| EP-0005783-B1 | IMIDAZO (2.1-B)-(1.3.4)-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |