Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 6/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4299773 | 1.00 | KDM5A (0.40) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL8526562 | 0.90 | KDM5A (0.47) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL690298 | 0.90 | KDM5A (0.47) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL29280736 | 0.90 | KDM5A (0.47) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL690693 | 0.90 | KDM5A (0.47) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL29403129 | 0.90 | KDM5A (0.47) | KDM5AKDM4CPHF8EPHX2KDM5C | |
| SCHEMBL4334125 | 0.85 | KDM5A (0.37) | KDM5AKDM4CPHF8EPHX2FFAR4 | |
| SCHEMBL4325880 | 0.85 | KDM5A (0.37) | KDM5AKDM4CPHF8EPHX2FFAR4 | |
| SCHEMBL21048580 | 0.85 | KDM5A (0.37) | KDM5AKDM4CPHF8EPHX2FFAR4 | |
| SCHEMBL2192540 | 0.85 | KDM5A (0.47) | KDM5AKDM4CPHF8FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034019-B1 | COMPOSITION FOR NUCLEIC-ACID INTRODUCTION | HOKKAIDO SYSTEM SCIENCE CO LTD (JP) | 2014-08-20 | — | — | EP | disclosed |
| US-8227248-B2 | Composition for nucleic-acid transfection | HOKKAIDO SYSTEM SCIENCE CO., LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| US-20090239222-A1 | COMPOSITION FOR NUCLEIC-ACID TRANSFECTION | HOKKAIDO SYSTEM SCIENCE CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-2034019-A1 | COMPOSITION FOR NUCLEIC-ACID INTRODUCTION | Hokkaido System Science Co., Ltd. (JP) | 2009-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239222-A1 | COMPOSITION FOR NUCLEIC-ACID TRANSFECTION | HNRNPH3, RNASEH1, NSUN3 | KDM5A 4776/4885KDM4C 4396/4885PHF8 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.