Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11591788 | 0.95 | FFAR3 (0.37) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| Ammonia Solution, Strong SCHEMBL28110714 | 0.78 | — | — | |
| SCHEMBL4951799 | 0.77 | CHRM1 (0.38) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3421509 | 0.77 | ALDH1A1 (0.35) | TDP1ALDH1A1 | |
| SCHEMBL8927706 | 0.76 | — | — | |
| SCHEMBL1196751 | 0.74 | — | — | |
| SCHEMBL20299941 | 0.74 | ALDH1A1 (0.43) | TDP1TP53ALDH1A1TSHR | |
| SCHEMBL7773740 | 0.74 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL7773743 | 0.74 | EPHX1 (0.39) | TDP1SMN1; SMN2ALDH1A1TSHRCA2 | |
| SCHEMBL155485 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009156620-A1 | ABSORBENT SOLUTION CONTAINING A DEGRADATION MULTISULPHUR-CONTAINING INHIBITOR HAVING A CARBOXYL GROUP AND METHOD FOR LIMITING THE DEGRADATION OF AN ABSORBENT SOLUTION | IFP (FR) | 2009-12-30 | — | — | WO | claimed |
| US-11053249-B2 | Proteasome inhibiting β-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders | PHILIPPE YVES-REMY SIMON (FR) | 2021-07-06 | — | — | US | disclosed |
| US-20200216455-A1 | Proteasome Inhibiting Beta-Lactam Produrgs Useful for the Treatment of Cancer and Nurodegenerative Disorders | VITA API (FR) | 2020-07-09 | — | — | US | disclosed |
| WO-2018115497-A1 | PROTEASOME INHIBITING ß-LACTAM PRODRUGS USEFUL FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS | VITA API (FR) | 2018-06-28 | — | — | WO | disclosed |
| WO-2009156620-A1 | ABSORBENT SOLUTION CONTAINING A DEGRADATION MULTISULPHUR-CONTAINING INHIBITOR HAVING A CARBOXYL GROUP AND METHOD FOR LIMITING THE DEGRADATION OF AN ABSORBENT SOLUTION | IFP (FR) | 2009-12-30 | — | — | WO | disclosed |
| WO-1991002741-A1 | SUGAR ALCOHOL DERIVATIVES, A PROCESS FOR PREPARING 3-DEOXY-2-OCTULOSONIC ACID AND 3-DEOXY-2-HEPTULOSONIC ACID COMPOUNDS AND DERIVATIVES | RIJKSUNIVERSITEIT TE LEIDEN (NL) | 1991-03-07 | — | — | WO | disclosed |
| EP-0310484-A1 | Derivatives of alkadienes, their preparations, medicinal compositions containing them, and intermediates | RHONE-POULENC SANTE (FR) | 1989-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11053249-B2 | Proteasome inhibiting β-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders | PSMB5, PSMB1, PSMB11 | TDP1 726/4885CHRM1 4159/4885AKR1A1 1881/4885 |
| US-20200216455-A1 | Proteasome Inhibiting Beta-Lactam Produrgs Useful for the Treatment of Cancer and Nurodegenerative Disorders | PSMB5, PSMB1, PSMB11 | TDP1 849/4885CHRM1 3616/4885AKR1A1 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.