Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | USP19 | O94966 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289705 | 0.94 | USP19 (0.36) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4293872 | 0.93 | USP19 (0.39) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4281650 | 0.93 | USP19 (0.39) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL13705395 | 0.92 | DPP4 (0.39) | DPP4USP19RENCHRNA7 | |
| SCHEMBL4292735 | 0.92 | USP19 (0.36) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4292301 | 0.92 | USP19 (0.36) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4286557 | 0.92 | DPP4 (0.39) | DPP4USP19REN | |
| SCHEMBL4293870 | 0.89 | USP19 (0.35) | DPP4USP19HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4283650 | 0.88 | USP19 (0.36) | DPP4USP19HCRTR1HCRTR2 | |
| SCHEMBL13705378 | 0.86 | USP19 (0.38) | DPP4USP19HCRTR1HCRTR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | DPP4 113/4885NAMPT 638/4885USP19 1993/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | DPP4 113/4885NAMPT 638/4885USP19 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.