Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15122119 | 0.97 | NOS3 (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGNOS3 | |
| SCHEMBL6695725 | 0.93 | CACNB4 (0.43) | NOS3NOS1NOS2PDE4BMEN1 | |
| SCHEMBL421347 | 0.88 | NOS1 (0.48) | PIK3CDPIK3CANOS3NOS1NOS2 | |
| SCHEMBL220177 | 0.88 | CACNB4 (0.41) | NOS3NOS1NOS2PDE4BMEN1 | |
| SCHEMBL6587914 | 0.87 | CHEK2 (0.43) | PIK3CDNOS3NOS1NOS2MEN1 | |
| SCHEMBL6583140 | 0.85 | ALOX5AP (0.46) | PIK3CDNOS3NOS1NOS2PDE4B | |
| SCHEMBL221708 | 0.84 | NOS1 (0.45) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL4898636 | 0.84 | CACNB4 (0.39) | NOS3NOS1NOS2PDE4BMEN1 | |
| SCHEMBL957928 | 0.83 | NOS3 (0.47) | PIK3CDNOS3NOS1NOS2CHEK2 | |
| 2-Aminopyridine SCHEMBL6585312 | 0.83 | NOS1 (0.46) | PIK3CDPIK3CANOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158646-A1 | THERAPEUTIC COMPUNDS AND RELATED METHODS OF USE | ELIXIR PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |