Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 2/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289837 | 0.78 | CHKA (0.55) | CHKAKDM4EALDH1A1PDE2A | |
| SCHEMBL2802324 | 0.77 | KDM4E (0.40) | DPP4COMTKDM4EALDH1A1PARP1 | |
| SCHEMBL3397376 | 0.74 | GFER (0.51) | CHKAKDM4EALDH1A1PDE2A | |
| SCHEMBL4296929 | 0.73 | L3MBTL1 (0.51) | PIK3CDKDM4EALDH1A1 | |
| SCHEMBL2106701 | 0.72 | ALDH1A1 (0.46) | CHKAKDM4EALDH1A1PDE2AFPR3 | |
| SCHEMBL4287610 | 0.71 | KDM4E (0.39) | CHKAKDM4EALDH1A1PDE2A | |
| SCHEMBL18609944 | 0.71 | PIK3CD (0.70) | PIK3CDDPP4P2RX7PARP1SLC2A1 | |
| SCHEMBL1427472 | 0.71 | ALDH1A1 (0.49) | CHKAKDM4EALDH1A1PDE2A | |
| SCHEMBL26133752 | 0.70 | NR1H2 (0.45) | PIK3CDDPP4COMTKDM4EALDH1A1 | |
| SCHEMBL26133559 | 0.70 | TLR7 (0.42) | PIK3CDDPP4CHKAALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | PIK3CD 400/4885DPP4 2887/4885COMT 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.