Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4291674 | 1.00 | PTGDR2 (0.48) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL4291683 | 0.86 | MEN1 (0.50) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL13780770 | 0.78 | MEN1 (0.50) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL6687183 | 0.68 | PTGDR2 (0.72) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL9016508 | 0.68 | PTGDR2 (0.62) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL354835 | 0.67 | PTGDR2 (1.00) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL28517834 | 0.65 | HSD17B10 (0.63) | KMT2AGAAMEN1ALDH1A1KDM4E | |
| SCHEMBL3706902 | 0.64 | PTGDR2 (0.56) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL11749993 | 0.64 | KDM4E (0.57) | PTGDR2TDP1KMT2AGAAMEN1 | |
| SCHEMBL11749279 | 0.64 | KMT2A (0.57) | PTGDR2TDP1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-07-09 | — | — | US | claimed |
| WO-2008054475-A2 | NEURAMINIDASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-05-08 | — | — | WO | claimed |
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-07-09 | — | — | US | disclosed |
| WO-2008054475-A2 | NEURAMINIDASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175805-A1 | Neuraminidase Inhibitors and uses thereof | ENGASE, NEU1, NEU2 | PTGDR2 4116/4885TDP1 822/4885KMT2A 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.