Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1567701 | 0.74 | NISCH (0.50) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL1079302 | 0.73 | NISCH (0.48) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL31276822 | 0.73 | NISCH (0.48) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL1890902 | 0.73 | NISCH (0.53) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL8347684 | 0.73 | NISCH (0.48) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL266615 | 0.73 | NISCH (0.48) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL2210580 | 0.73 | NISCH (0.48) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL447295 | 0.73 | NISCH (0.53) | NISCHADRA2AADRA1AHTTHTR1A | |
| SCHEMBL2319338 | 0.73 | NISCH (0.53) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL963837 | 0.73 | NISCH (0.53) | NISCHABCG2ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829028-B2 | 5-HT4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2014-09-09 | — | — | US | claimed |
| US-20090169545-A1 | 5-HT4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE | SERODUS AS (NO) | 2009-07-02 | — | — | US | claimed |
| US-20060094715-A1 | 5-Ht4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2006-05-04 | — | — | US | claimed |
| US-10882865-B2 | Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2021-01-05 | — | — | US | disclosed |
| US-20200071334-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2020-03-05 | — | — | US | disclosed |
| WO-2014200682-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10882865-B2 | Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity | GAA, GBA1, GBA3 | NISCH 1754/4885ABCG2 608/4885ITGB2 4820/4885 |
| US-20200071334-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GAA, GBA3, GBA1 | NISCH 1316/4885ABCG2 549/4885ITGB2 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.