Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493018 | 0.81 | SMN1; SMN2 (0.61) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL896833 | 0.81 | SMN1; SMN2 (0.61) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL2061817 | 0.78 | ITGB2 (0.52) | NISCHABCG2ITGB2ICAM1ITGAL | |
| SCHEMBL18365855 | 0.78 | ABCG2 (0.50) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL17816166 | 0.77 | NISCH (0.48) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL4773404 | 0.75 | CHRNB4 (0.50) | CA2 | |
| SCHEMBL1567701 | 0.74 | NISCH (0.50) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL14322211 | 0.74 | NISCH (0.32) | NISCH | |
| SCHEMBL5731128 | 0.73 | ABCG2 (0.50) | NISCHADRA2AADRA1AHTR1ADRD1 | |
| SCHEMBL20241876 | 0.73 | ADRA2A (0.54) | NISCHADRA2AADRA1AHTR1AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260069599-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 AND PHOSPHOINOSITIDE 3-KINASE | UNIV NEBRASKA (US) | 2026-03-12 | — | — | US | claimed |
| WO-2024050505-A2 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 AND PHOSPHOINOSITIDE 3-KINASE | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2024-03-07 | — | — | WO | claimed |
| US-20150031705-A1 | OPHTHALMIC FORMULATIONS INCLUDING SELECTIVE ALPHA 1 ANTAGONISTS | OCULARIS PHARMA LLC (US) | 2015-01-29 | — | — | US | claimed |
| EP-1755591-A4 | OPHTHALMIC FORMULATIONS INCLUDING SELECTIVE ALPHA 1 ANTAGONISTS | OCULARIS PHARMA INC (US) | 2007-11-07 | — | — | EP | claimed |
| EP-1755591-A2 | OPHTHALMIC FORMULATIONS INCLUDING SELECTIVE ALPHA 1 ANTAGONISTS | Ocularis Pharma, Inc. (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005123093-A2 | OPHTHALMIC FORMULATIONS INCLUDING SELECTIVE ALPHA 1 ANTAGONISTS | OCULARIS PHARMA, INC. (US) | 2005-12-29 | — | — | WO | claimed |
| US-20050080056-A1 | Alpha 1 antagonist; reduces pupil size in dim light, but less reduction in pupil size in bright light; artificial tear; tamsulosin, urapidil | Ocuphire Pharma, Inc. | 2005-04-14 | — | — | US | claimed |
| CN-116710783-A | Detection of target analytes by cross-spray ESI mass spectrometry | 豪夫迈·罗氏有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-116323568-A | Detection of target analytes by nanoESI mass spectrometry | 豪夫迈·罗氏有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-106167483-B | It can be used for compound, composition and the method for cholesterol mobilization | 塞伦尼斯医疗控股有限公司 | 2019-02-15 | — | — | CN | disclosed |
| CN-107011359-A | Compound, composition and the method mobilized available for cholesterol | 塞伦尼斯医疗控股有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-103442714-B | Compounds, compositions and methods useful for cholesterol mobilization | 塞伦尼斯医疗控股有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-106167483-A | Can be used for compound, compositions and method that cholesterol is mobilized | 塞伦尼斯医疗控股有限公司 | 2016-11-30 | — | — | CN | disclosed |
| US-5578697-A | DIELECTRIC POLYMERS FOR ELECTRONICS | KABUSHIKI KAISHA TOSHIBA (JP) | 1996-11-26 | — | — | US | disclosed |
| EP-0429535-A1 | FUNGICIDAL BENZODIOXANE AMINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-06-05 | — | — | EP | disclosed |
| EP-0429535-A1 | FUNGICIDAL BENZODIOXANE AMINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-06-05 | — | — | EP | disclosed |
| EP-0359400-A1 | Fungicidal benzodioxane amine derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0359400-A1 | Fungicidal benzodioxane amine derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1990002122-A1 | FUNGICIDAL BENZODIOXANE AMINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-08 | — | — | WO | disclosed |
| WO-1990002122-A1 | FUNGICIDAL BENZODIOXANE AMINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260069599-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 AND PHOSPHOINOSITIDE 3-KINASE | BRD4, BRD3, BRPF3 | NISCH 4675/4885ADRA2A 2798/4885ADRA1A 2298/4885 |
| US-20150031705-A1 | OPHTHALMIC FORMULATIONS INCLUDING SELECTIVE ALPHA 1 ANTAGONISTS | ADRA1D, ADRA1A, ADRA1B | NISCH 578/4885ADRA2A 5/4885ADRA1A 2/4885 |
| US-20050080056-A1 | Alpha 1 antagonist; reduces pupil size in dim light, but less reduction in pupil size in bright light; artificial tear; tamsulosin, urapidil | ADRA1A, ADRA1D, ADRA2A | NISCH 432/4885ADRA2A 3/4885ADRA1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.