SCHEMBL4291960

SCHEMBL4291960

CC(=O)C(N)C(N)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.55
SLC1A3 P43003 3/20 0.46
SLC1A2 P43004 3/20 0.46
SLC1A1 P43005 3/20 0.46
USP2 O75604 1/20 0.37
SLCO1B1 Q9Y6L6 1/20 0.37
PTGS1 P23219 2/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
GRIK1 P39086 1/20 0.36
FFAR3 O14843 1/20 0.35
LCK P06239 1/20 0.35
FYN P06241 1/20 0.35
TP53 P04637 1/20 0.35
GLO1 Q04760 1/20 0.34
GSR P00390 1/20 0.33
SLC7A11 Q9UPY5 1/20 0.33
LMNA P02545 1/20 0.33
ALOX15 P16050 1/20 0.33
BLM P54132 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18286558 0.87 LMNA (0.43) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1
SCHEMBL9617308 0.87 LMNA (0.43) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1
SCHEMBL468084 0.83 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL29957453 0.83 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL25933046 0.83 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL600021 0.83 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL1007447 0.83 SLC7A5 (0.62) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL4632980 0.79 SLC7A5 (0.59) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL4633860 0.79 SLC7A5 (0.59) SLC7A5SLC1A3SLC1A2SLC1A1USP2
Hydrochloric Acid SCHEMBL11095114 0.79 SLC7A5 (0.59) SLC7A5SLC1A3SLC1A2SLC1A1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112585157-A Peptide ligands for binding integrin α v β 3 拜斯科技术开发有限公司 2021-03-30 CN claimed
US-20180298055-A1 INHIBITORS OF NF KAPPA-B ACTIVITY FOR TREATMENT OF DISEASES AND DISORDERS BHATNAGAR RAJENDRA SAHAI (US) 2018-10-18 US claimed
US-10030048-B2 Inhibitors of NF κ-B activity for treatment of diseases and disorders BHATNAGAR RAJENDRA SAHAI (US) 2018-07-24 US claimed
US-7015309-B1 Pyrrhocoricin-derived peptides, and methods of use thereof THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2006-03-21 US claimed
EP-1194548-A4 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF WISTAR INST (US) 2003-06-18 EP claimed
EP-1194548-A1 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2002-04-10 EP claimed
WO-2000078956-A1 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2000-12-28 WO claimed
US-20240180997-A1 PEPTIDE INHIBITORS OF NF KAPPA B AND USE THEREOF IN TREATMENT OF COVID-19 AND INFLAMMATORY DISEASES BHATNAGAR RAJENDRA SAHAI (US) 2024-06-06 US disclosed
US-20240083941-A1 INHIBITORS OF NF KAPPA-B ACTIVITY FOR TREATMENT OF DISEASES AND DISORDERS BHATNAGAR RAJENDRA SAHAI (US) 2024-03-14 US disclosed
US-11773135-B2 Inhibitors of NF kappa-B activity for treatment of diseases and disorders BHATNAGAR RAJENDRA SAHAI (US) 2023-10-03 US disclosed
EP-4203988-A2 PEPTIDE INHIBITORS OF NF KAPPA B AND USE THEREOF IN TREATMENT OF COVID-19 AND INFLAMMATORY DISEASES Bhatnagar, Rajendra, Sahai (US) 2023-07-05 EP disclosed
EP-3197474-B1 INHIBITORS OF NF KAPPA-B ACTIVITY FOR TREATMENT OF DISEASES AND DISORDERS BHATNAGAR RAJENDRA SAHAI (US) 2023-06-07 EP disclosed
CN-114432423-A NF for treating diseases and disorderskInhibitors of B activity 拉金德拉·萨哈伊·巴特纳格尔 2022-05-06 CN disclosed
US-20050181987-A1 Compositions and methods for treatment of cancer THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2005-08-18 US disclosed
EP-1194548-A4 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF WISTAR INST (US) 2003-06-18 EP disclosed
WO-2000027420-A9 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 2002-04-25 WO disclosed
EP-1194548-A1 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2002-04-10 EP disclosed
WO-2000078956-A1 NOVEL PYRRHOCORICIN-DERIVED PEPTIDES, AND METHODS OF USE THEREOF THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2000-12-28 WO disclosed
WO-2000027420-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2000-05-18 WO disclosed
WO-1992002543-A1 NOVEL IMMUNOSUPPRESSANT PEPTIDES CYTEL CORPORATION (US) 1992-02-20 WO disclosed