Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | RPLP1 | P05386 | 7/20 | 0.34 |
| ▸ | RPLP0 | P05388 | 7/20 | 0.34 |
| ▸ | RPS17 | P08708 | 7/20 | 0.34 |
| ▸ | RPSA | P08865 | 7/20 | 0.34 |
| ▸ | RPS2 | P15880 | 7/20 | 0.34 |
| ▸ | RPL35A | P18077 | 7/20 | 0.34 |
| ▸ | RPL7 | P18124 | 7/20 | 0.34 |
| ▸ | RPL17 | P18621 | 7/20 | 0.34 |
| ▸ | RPS4Y1 | P22090 | 7/20 | 0.34 |
| ▸ | RPS3 | P23396 | 7/20 | 0.34 |
| ▸ | RPS12 | P25398 | 7/20 | 0.34 |
| ▸ | RPL13 | P26373 | 7/20 | 0.34 |
| ▸ | RPL10 | P27635 | 7/20 | 0.34 |
| ▸ | RPL12 | P30050 | 7/20 | 0.34 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 7/20 | 0.34 |
| ▸ | RPL22 | P35268 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292339 | 1.00 | OPRM1 (0.40) | OPRM1HRH3SLC6A2SLC6A4RPLP1 | |
| SCHEMBL4292343 | 1.00 | OPRM1 (0.40) | OPRM1HRH3SLC6A2SLC6A4RPLP1 | |
| SCHEMBL4301772 | 0.91 | HRH3 (0.39) | OPRM1HRH3RPLP1RPLP0RPS17 | |
| SCHEMBL4301777 | 0.91 | HRH3 (0.39) | OPRM1HRH3RPLP1RPLP0RPS17 | |
| SCHEMBL4301775 | 0.91 | HRH3 (0.39) | OPRM1HRH3RPLP1RPLP0RPS17 | |
| SCHEMBL4296089 | 0.85 | OPRM1 (0.42) | OPRM1HRH3CA12CA1CA2 | |
| SCHEMBL4295444 | 0.85 | TACR1 (0.40) | OPRM1HRH3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL4295450 | 0.85 | TACR1 (0.40) | OPRM1HRH3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL4295438 | 0.85 | TACR1 (0.40) | OPRM1HRH3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL7105668 | 0.81 | HRH3 (0.40) | HRH3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | APODACA RICHARD | 2009-10-22 | — | — | US | claimed |
| US-20050288323-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | APODACA RICHARD | 2005-12-29 | — | — | US | claimed |
| US-20040167336-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | APODACA RICHARD (US) | 2004-08-26 | — | — | US | claimed |
| US-20030013733-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-01-16 | — | — | US | claimed |
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | APODACA RICHARD | 2009-10-22 | — | — | US | disclosed |
| US-20050288323-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | APODACA RICHARD | 2005-12-29 | — | — | US | disclosed |
| US-20040167336-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | APODACA RICHARD (US) | 2004-08-26 | — | — | US | disclosed |
| US-20030013733-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288323-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | HRH4, HNMT, HRH1 | OPRM1 49/4885HRH3 7/4885SLC6A2 644/4885 |
| US-20030013733-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | HRH4, HNMT, HRH1 | OPRM1 49/4885HRH3 7/4885SLC6A2 644/4885 |
| US-20040167336-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | HRH4, HNMT, HRH1 | OPRM1 49/4885HRH3 7/4885SLC6A2 644/4885 |
| US-20090263322-A1 | OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES | HRH4, HNMT, HRH1 | OPRM1 51/4885HRH3 7/4885SLC6A2 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.