Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206060 | 0.82 | NR4A1 (0.48) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7793793 | 0.81 | MAOB (0.37) | PARP1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL10915695 | 0.74 | KDM4E (0.50) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL10482945 | 0.74 | KDM4E (0.45) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL2584051 | 0.73 | PARP1 (0.43) | PARP1ALDH1A1PLK4MAP4K4PRKX | |
| SCHEMBL5748948 | 0.73 | KDM4E (0.63) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL5748816 | 0.73 | KDM4E (0.63) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL14660905 | 0.72 | KDM4E (0.43) | PARP1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL3980872 | 0.72 | KDM4E (0.43) | PARP1KDM4EALDH1A1GAAPDPK1 | |
| SCHEMBL1893396 | 0.72 | PARP1 (0.44) | PARP1KDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281897-A1 | Potentialization of the activation of high molecular weight prodrugs | DIATOS S.A. (FR) | 2006-12-14 | — | — | US | claimed |
| US-20090220529-A1 | Anticancer Drugs Conjugated to Antibody via an Enzyme Cleavable Linker | DIATOS, S.A. (FR) | 2009-09-03 | — | — | US | disclosed |
| EP-1993608-A1 | ANTICANCER DRUGS CONJUGATED TO ANTIBODY VIA AN ENZYME CLEAVABLE LINKER | Diatos (FR) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008120098-A2 | PEPTIDE PRODRUGS | DIATOS (FR) | 2008-10-09 | — | — | WO | disclosed |
| EP-1977765-A1 | Peptide prodrugs | Diatos (FR) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007105027-A1 | ANTICANCER DRUGS CONJUGATED TO ANTIBODY VIA AN ENZYME CLEAVABLE LINKER | DIATOS (FR) | 2007-09-20 | — | — | WO | disclosed |
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| US-20060281897-A1 | Potentialization of the activation of high molecular weight prodrugs | DIATOS S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281897-A1 | Potentialization of the activation of high molecular weight prodrugs | CD44, MMP12, FOLH1 | PARP1 139/4885KDM4E 3907/4885ALDH1A1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.