Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129592 | 0.73 | IMPDH2 (0.55) | PARP1PIM1DYRK1APIM3DHODH | |
| SCHEMBL30006934 | 0.73 | IMPDH2 (0.55) | PARP1PIM1DYRK1APIM3DHODH | |
| SCHEMBL4292765 | 0.73 | PARP1 (0.46) | PARP1PARP2PLK4MAP4K4PRKX | |
| SCHEMBL2470259 | 0.72 | ALDH1A1 (0.54) | PARP1PIM1PIM3ALDH1A1ATM | |
| SCHEMBL2388664 | 0.71 | ALDH1A1 (0.39) | ALDH1A1ATM | |
| SCHEMBL30007584 | 0.69 | PARP1 (0.44) | PARP1PIM1PIM3DHODHALDH1A1 | |
| SCHEMBL15995219 | 0.68 | HTR7 (0.46) | PARP1CHEK2ALDH1A1 | |
| SCHEMBL9149047 | 0.67 | PIM1 (0.50) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL30849286 | 0.67 | KIF11 (0.50) | PARP1CAMK2BCAMK2GCAMK2DALDH1A1 | |
| SCHEMBL10482945 | 0.66 | KDM4E (0.45) | PARP1ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137390-A1 | TREATMENT OF MAJOR ADVERSE CARDIAC EVENTS AND ACUTE CORONARY SYNDROME IN DIABETIC PATIENTS USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITOR OR SPLA2 INHIBITOR COMBINATION THERAPIES | ANTHERA PHARMACEUTICALS, INC. (US) | 2011-11-03 | — | — | WO | disclosed |